Introduction:
Pregnancy-related anxiety has negatively affected maternal, fetal, neonatal, and child health. It increases the risk of maternal antenatal depression, preeclampsia/eclampsia, prolonged labor, preterm birth, low birth weight, and unplanned cesarean section. Globally, it is one of the most common mental health problems among pregnant mothers. This study aimed to assess the prevalence and determinants of pregnancy-related anxiety and associated factors among pregnant women attending antenatal care services at Gondar city public health facilities, northwest Ethiopia.

Methods:
An institution-based cross-sectional study was conducted at Gondar city, at eight public health facilities, northwest Ethiopia, on February 15-30, 2022. A systematic random sampling technique was used to select pregnant mothers to participate in this study. A structured, pretested, and interviewer-administered questionnaire was used for data collection. The collected data were entered with EpiData version 4.6 and then exported to SPSS version 25. Both bi-variable and multivariable logistic regression analyses were undertaken to identify significantly associated variables with pregnancyrelated anxiety. The adjusted odds ratio (AOR) with its 95% confidence interval (CI) at a p-value of ≤0.05 was used to claim statistical association.

Results:
About 416 respondents out of 422 pregnant women were interviewed, making a response rate of 98.6 %. The prevalence and determinants of pregnancy-related anxiety were found to be 33.7% (95% CI [29.3, 38.5%]). Gestational age ≤28 weeks (AOR=2.27, 95% CI: [1.46, 3.55], P=0.000), primigravida (AOR=1.70, 95% CI: [1.03, 2.81], P=0.04), and having a history of mental illness (AOR=3.13, 95% CI [1.10, 8.91], P=0.03) were significantly associated with pregnancy-related anxiety.

Conclusions:
In this study, the prevalence of pregnancy-related anxiety was high. The healthcare providers who work in the ANC outpatient department need mental health screening in their routine ANC services, giving interventions to pregnant mothers who have a history of early pregnancy and mothers who are primigravida.